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1996-02-27
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Document 0620
DOCN M9630620
TI Replication of molluscum contagiosum virus.
DT 9603
AU Buller RM; Burnett J; Chen W; Kreider J; Laboratory of Viral Diseases,
National Institute of Allergy and; Infectious Diseases, National
Institutes of Health, Bethesda,; Maryland 20892, USA.
SO Virology. 1995 Nov 10;213(2):655-9. Unique Identifier : AIDSLINE
MED/96074540
AB Molluscum contagiosum virus (MCV) infects preadolescent children and
sexually active adults, frequently causing a disfiguring cutaneous
disease in immunosuppressed HIV-infected individuals. The development of
an efficacious treatment regime has been hampered by the failure to
replicate the virus in the laboratory. Here we report the first
demonstration of MCV replication in an experimental system. In human
foreskin grafts to athymic mice, MCV induced morphological changes which
were indistinguishable from patient biopsies and included the
development and migration of molluscum bodies containing mature virions
to the epidermal surface.
DE Animal DNA, Viral/*ANALYSIS Human Infant, Newborn Male Mice Mice,
Nude Molluscum Contagiosum/PATHOLOGY/*VIROLOGY Molluscum Contagiosum
Virus/ISOLATION & PURIF/*PHYSIOLOGY Skin/PATHOLOGY/*VIROLOGY Skin
Transplantation Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S.
Transplantation, Heterologous Virion/METABOLISM Virus Replication
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).